Endoca CBD Suppositories 500mg CBD 10 Pieces
Each package contains 10 suppositories with 50mg of CBD each.
For rectal use or as vaginal capsule. Refrigerate before using. Use good hygiene and wash hands before and after use. To remove suppository, tear the plastic shell lengthwise beginning at the “V” shaped cut at the pointed end of the suppository. Apply a light coating of water lubricant to the suppository before insertion. FOR RECTAL INSERTION: insert suppository past sphincter muscle. Try to wait 15 to 20 minutes before another bowel movement. Broken suppositories may be reheated in the shells in a sealable waterproof bag in warm water until melted and then reformed in a refrigerator. Occasional air bubbles in suppository are normal and do not indicate a loss of product. FOR VAGINAL INSERTION: Capsule to be inserted high in the vagina. This is best done in a reclining position.
Suppositories should be stored in the fridge (at 2°C to 8°C).
Standardized extracts are guaranteed to contain a specific quantity of Cannabinoids, and are laboratory tested to insure consistent potency; manufacturd to GMP(Good Manufacturing Practices) standards and are free of synthetic ingredients.
Bioavailability of cannabis suppositories
There are many advantages to the rectal administration of cannabis compared to the other routes. If the oral route is disallowed due to oral intake restrictions frequently required both before and after surgery, or if the oral route is impaired due to e.g. vomiting, injured jaw or throat, or gastrointestinal difficulties, it is still be possible to administer Cannabis rectally. Rectal administration of cannabis makes it possible to avoid drug degradation in the gastrointestinal tract and bypass first pass metabolism in the liver. This allows the cannabinoids to reach the blood in much higher concentrations (1). Rectal administration allows avoidance of these effects and furthermore, a greater proportion of CBD is allowed to eventually reach the blood stream. This form for administration offers a much faster uptake than oral administration (approximately 10 minutes, on average). The speed and reliability of their uptake combined with their circumvention of many issues surrounding both ingestion and inhalation make rectal applications an excellent addition to both new and pre-existing therapeutic regimens. With suppositories, initial effects will most often be noticed within 10-15 minutes after application, and these effects will usually last 4-8 hours depending on the physiology and tolerance for cannabis of the individual. However, there are several issues that can slow absorption from the rectum to the blood stream. Diarrhea, fecal matter and tumors or cysts on the rectum wall can slow or prevent the cannabinoids from reaching the rectal wall and being absorbed. Rectal dehydration can also drastically reduce the effectiveness of suppositories. Staying well hydrated by maintaining a healthy consumption of both water and electrolytes may prevent this. However, specific medical condition may also cause rectal dehydration, in which case the solution may not be as simple. In case of concern, medical professionals should be consulted. Suppositories can be used to refine existing therapeutic regimens to greater effects. People, who have been prevented from using cannabis due to inability to administer via ingestion or inhalation, can potentially derive benefit from cannabis for the first time by using cannabis suppositories. The bioavailabilities of cannabinoids for the aforementioned administration routes are illustrated in figure 1.
Figure 1: Comparative bioavailability of various cannabinoids of different administration routes.
This statement has not been evaluated by the FDA. Pregnant women and lactating mothers should not use this product. Always consult a medical doctor before modifying your diet or using any new product. This product is not intended to diagnose, treat, cure, or prevent any disease.
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